Day: January 26, 2022
Vaccinia virus Recombinants
Description Recombinant vaccinia virus is produced by homologous recombination between a plasmid and viral DNA within infected cells. The gene of interest is inserted at a nonessential locus in vaccinia DNA or between two essential genes to minimize unstable recombinants. To aid in the recovery of the recombinant virus, plasmids have been generated that allow …
Plasmodium falciparum Recombinants
Bottom The human malaria parasite Plasmodium falciparum recombinants survives pressures from the host’s immune system and antimalarial drugs by modifying its genome. Genetic recombination and nucleotide substitution are the two main mechanisms used by the parasite to generate genomic diversity. A better understanding of these mechanisms may provide important information for studying parasite evolution, immune …